Role of chromatin/epigenetic modifications on DNA accessibility.
Drug News Perspect
; 20(9): 549-56, 2007 Nov.
Article
em En
| MEDLINE
| ID: mdl-18176659
ABSTRACT
From a therapeutic, and more precisely a DNA-drug interactions point of view, multiple factors can regulate DNA accessibility. In addition to various levels of chromatin compaction described in this review, DNA modifications such as methylation, the presence of specific DNA-binding proteins and chromatin-associated proteins, and, as was shown more recently, noncoding RNA can also contribute. The present review will discuss the importance of these epigenetic factors in modulating drug binding to DNA and the potential design of new therapeutic regimens aimed at improving DNA targeting.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Cromatina
/
Epigênese Genética
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article