Cationic palladium(II)-catalyzed stereoselective glycosylation with glycosyl trichloroacetimidates.
J Org Chem
; 73(3): 794-800, 2008 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-18184010
ABSTRACT
The development of a new method for stereoselective glycosylation with glycosyl trichloroacetimidate donors employing cationic palladium(II), Pd(CH(3)CN)(4)(BF(4))(2), is described. This process employs Pd(CH(3)CN)(4)(BF(4))(2) as an efficient activator, providing access to a variety of disaccharides and glycopeptides. This reaction is highly stereoselective and proceeds under mild conditions with low catalyst loading. Interestingly, this palladium catalysis directs beta-glucosylations in the absence of classical neighboring group participation.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article