Theory and generalization of Monte Carlo models of the BOLD signal source.
Magn Reson Med
; 59(3): 607-18, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-18224696
ABSTRACT
The dependency of the blood oxygenation level dependent (BOLD) signal on underlying hemodynamics is not well understood. Building a forward biophysical model of this relationship is important for the quantitative estimation of the hemodynamic changes and neural activity underlying functional magnetic resonance imaging (fMRI) signals. We have developed a general model of the BOLD signal which can model both intra- and extravascular signals for an arbitrary tissue model across a wide range of imaging parameters. The model of the BOLD signal was instantiated as a look-up-table (LuT), and was verified against concurrent fMRI and optical imaging measurements of activation induced hemodynamics.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Imageamento por Ressonância Magnética
/
Método de Monte Carlo
Tipo de estudo:
Health_economic_evaluation
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article