[Pharmacology of cannabinoid receptors]. / Pharmacologie des récepteurs cannabinoïdes.
Bull Acad Natl Med
; 191(4-5): 933-8; discussion 938-40, 2007.
Article
em Fr
| MEDLINE
| ID: mdl-18225447
ABSTRACT
The endocannabinoid (EC) system is a physiological system with an important regulatory role in numerous biological functions, both centrally and peripherally. In certain conditions it can become hyperactive and induce a variety of disorders. The system has two receptor types, designated CB1 and CB2 (present respectively in the CNS and the periphery), as well as endogenous ligands (AEA and 2-AG) and equipment for transporting, synthesizing and degrading them. The discovery of specific CB1 antagonists has opened up interesting new possibilities for the treatment of obesity, diabetes and cardiometabolic risk factors.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Pirazóis
/
Canabinoides
/
Diabetes Mellitus Tipo 2
/
Antagonistas de Receptores de Canabinoides
/
Obesidade
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
Fr
Ano de publicação:
2007
Tipo de documento:
Article