Isoxazoles from 1,1-Disubstituted Bromoalkenes.
Tetrahedron Lett
; 48(7): 1295-1298, 2007 Feb 12.
Article
em En
| MEDLINE
| ID: mdl-18265873
ABSTRACT
The regioselective synthesis of 3,5-disubstituted isoxazoles was achieved through the 1,3-dipolar cycloaddition of nitrile oxides with 1,1-disubstituted bromoalkenes. The substituted bromoalkenes function as alkyne synthons which were used to construct 5,5-disubstituted bromoisoxazoline intermediates that aromatize to the analogous isoxazoles through the loss of HBr.
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MEDLINE
Idioma:
En
Ano de publicação:
2007
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Article