Oxidation by hypochlorite converts protective HDL into a potent platelet agonist.
FEBS Lett
; 582(5): 778-84, 2008 Mar 05.
Article
em En
| MEDLINE
| ID: mdl-18267121
ABSTRACT
High density lipoproteins (HDL) represent a protective factor of central importance that counteracts the development of cardiovascular disease, in part by normalizing platelet (hyper)reactivity. As HDL represent an efficient scavenger of the naturally occurring oxidant hypochlorite, this work was intended to investigate the influence of hypochlorite-oxidized HDL on platelet function. Addition of hypochlorite-oxidized HDL to human platelets results in an immediate and transient raise in intracellular calcium, surface expression of P-selectin and platelet aggregation. The observed effects are dose dependent and can be blocked by an antibody directed against the lipoprotein-binding domain of platelet thrombospondin- and scavenger receptor CD36.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plaquetas
/
Ácido Hipocloroso
/
Lipoproteínas HDL
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article