Reversible medetomidine/ketamine anesthesia in captive capuchin monkeys (Cebus apella).
J Med Primatol
; 37 Suppl 1: 74-81, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-18269533
ABSTRACT
BACKGROUND:
Medetomidine, an alpha(2)-adrenergic receptor agonist administered with ketamine, induces sedation/anesthesia in non-human primates in a dose-dependent, species-specific manner.METHODS:
Two adult male capuchin monkeys enrolled in a study of kinematics of mastication were administered intramuscular (IM) injections of 150, 200 and 400 microg/kg medetomidine or medetomidine (microg/kg)/ketamine (mg/kg) at 200/2, 150/4. Medetomidine was reversed with atipamezole. Animals were then fed for 9-75 minutes. A second anesthesia reversal episode allowed return to home cage.RESULTS:
Medetomidine (150 microg/kg)/ketamine (4 mg/kg) provided anesthesia for handling and restraint within 10 minutes of administration. Atipamezole (750 microg/kg) IM provided reversal sufficient for the animal to eat by 22 minutes or perch by 31 minutes.CONCLUSIONS:
Medetomidine/ketamine administered IM in Cebus apella results in rapid, reproducible and safe anesthesia which is reversible with atipamezole. Nausea, vomiting or regurgitation were not observed during anesthesia reversal episodes in either the fasted or fed state.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cebus
/
Medetomidina
/
Anestesia
/
Ketamina
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article