Multianalyte quantification of five sesqui- and ethyl ether oxy-mustard metabolites in human urine by liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry.
J Anal Toxicol
; 32(1): 44-50, 2008.
Article
em En
| MEDLINE
| ID: mdl-18269792
ABSTRACT
Sesqui- and oxy-mustards pose a significant threat to military forces and civilians because they are potent vesicants. We have developed an isotope-dilution high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry method utilizing negative ion multiple reaction monitoring for the analysis of sesqui-mustard metabolites bis(2-hydroxyethylthio)alkanes (n = 1-5) and oxy-mustard metabolite bis(2-hydroxyethylthioethyl)ether in human urine. Relative standard deviations were < 10% and the reportable limits of detection were 1 ng/mL in 0.5 mL of urine. We applied this method to 100 samples collected from individuals with no known exposure to sesqui- or oxy-mustards, and no urines showed detectable levels of any of the analytes, suggesting that these metabolites may be used for monitoring exposure to sesqui- and oxy-mustards.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Monitoramento Ambiental
/
Espectrometria de Massas em Tandem
/
Gás de Mostarda
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article