Remodeling of heart and arteries by chronic converting enzyme inhibition in spontaneously hypertensive rats.
Am J Hypertens
; 4(3 Pt 2): 240S-245S, 1991 Mar.
Article
em En
| MEDLINE
| ID: mdl-1828353
ABSTRACT
Hemodynamic and structural changes of the heart and large arterial vessels were studied in normotensive and spontaneously hypertensive rats following 12 weeks administration of converting enzyme inhibitor (perindopril, 2 mg/kg daily by gavage). In both strains, a significant blood pressure reduction was observed. In normotensive rats, the hemodynamic changes involved significant increase in systemic arterial compliance whereas slight changes in left ventricular weight and aortic medial thickness were observed. In hypertensive rats, the increase in compliance was relatively small, whereas there was a major reduction in medial thickness. Furthermore, the reduction of the media thickness was much more pronounced than that of the left ventricular hypertrophy. The present results suggest that the cardiac and arterial changes observed following long term converting enzyme inhibition do not strictly parallel the blood pressure changes in hypertensive rats. Dissociation between cardiac and arterial changes may be observed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores da Enzima Conversora de Angiotensina
/
Hipertensão
/
Indóis
Limite:
Animals
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article