Feline immunodeficiency virus infection: a valuable model to study HIV-1 associated encephalitis.
Vet Immunol Immunopathol
; 123(1-2): 134-7, 2008 May 15.
Article
em En
| MEDLINE
| ID: mdl-18289700
ABSTRACT
Feline immunodeficiency virus (FIV), like human immunodeficiency virus (HIV)-1, is a neurotropic lentivirus and is associated with neuropathology in natural and experimental infections. FIV enters the brain early following experimental infection, and virus has been proposed to enter the brain via the blood-brain barrier and blood-CSF barrier, within infected lymphocytes and monocytes/macrophages. However the entry of cell-free virus or the direct infection of brain endothelial cells and astrocytes of the blood-brain barrier may also contribute to CNS infection. This review explores the role played by the FIV model in the elucidation of mechanism of lentiviral entry to the brain and viral interactions with the CNS, particularly in relation to lymphotropic lentiviruses.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Sistema Nervoso Central
/
Síndrome de Imunodeficiência Adquirida Felina
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HIV-1
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Vírus da Imunodeficiência Felina
/
Encefalite
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article