Upregulation of annexin A2 in H(2)O(2)-induced premature senescence as evidenced by 2D-DIGE proteome analysis.
Exp Gerontol
; 43(4): 353-9, 2008 Apr.
Article
em En
| MEDLINE
| ID: mdl-18289818
ABSTRACT
Human diploid fibroblasts undergo premature senescence after treatment with sublethal concentration of H(2)O(2). We report the first proteomic study of microsomal proteins in the context of H(2)O(2)-induced premature senescence by using 2D-DIGE approach. Twelve different proteins with altered abundance at day 3 after treatment with H(2)O(2) were identified. Among them, we demonstrated a re-localization of annexin A2 in plasma membrane.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Proteínas
/
Anexina A2
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article