Cutting edge: contributions of apoptosis and anergy to systemic T cell tolerance.
J Immunol
; 180(5): 2762-6, 2008 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-18292495
ABSTRACT
Multiple pathways can induce and maintain peripheral T cell tolerance. The goal of this study was to define the contributions of apoptosis and anergy to the maintenance of self-tolerance to a systemic Ag. Upon transfer into mice expressing OVA systemically, OVA-specific DO11 CD4+ T cells are activated transiently, cease responding, and die. Bim is the essential apoptosis-inducing trigger and apoptosis proceeds despite increased expression of Bcl-2 and Bcl-x. However, preventing apoptosis by eliminating Bim does not restore proliferation or cytokine production by DO11 cells. While Foxp3 is transiently induced, anergy is not associated with the stable development of regulatory T cells. Thus, apoptosis is dispensable for tolerance to a systemic self-Ag and cell-intrinsic anergy is sufficient to tolerize T cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Subpopulações de Linfócitos T
/
Apoptose
/
Deleção Clonal
/
Anergia Clonal
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article