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Hepatitis C virus presumably associated bilateral consecutive anterior ischemic optic neuropathy.
Fodor, M; Nagy, V; Berta, A; Tornai, I; Pfliegler, G.
Afiliação
  • Fodor M; Department of Ophthalmology, Medical and Health Sciences Center, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. mfodor@dote.hu
Eur J Ophthalmol ; 18(2): 313-5, 2008.
Article em En | MEDLINE | ID: mdl-18320531
PURPOSE: To report a case of bilateral nonarteritic anterior ischemic optic neuropathy (NAION) in a hepatitis C (HCV) infected patient and demonstrate the relationship between HCV and the development of NAION. METHODS: Case report. RESULTS: A 43-year-old woman with chronic HCV infection and long-term euthyroid autoimmune thyroiditis suddenly lost vision in her right eye, and 6 months later in her left eye, due to NAION. Slightly elevated levels of aminotransferases suggested liver infection activity. Anti-HCV antibody was detected; the genotype of the virus was 1b and the viral RNA level was 1.8 x 106 IU/mL. Liver biopsy proved chronic active hepatitis (Ishak score grading: 7, staging: 2). Except for the elevated levels of antithyroid antibodies and a weak antinuclear factor, the detailed laboratory examinations (thrombophilia, cryoglobulin, anticardiolipin antibodies, co-infections) revealed no other abnormalities; a causative relationship between the underlying chronic hepatitis C and bilateral NAION therefore seems probable. The patient was treated with pegylated interferon and ribavirin for 1 year and a sustained viral remission could be achieved. Her vision has neither improved nor deteriorated further. CONCLUSIONS: This appears to be the first reported case of bilateral NAION presumably caused by HCV infection.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepacivirus / Neuropatia Óptica Isquêmica / Hepatite C Crônica Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Adult / Female / Humans Idioma: En Ano de publicação: 2008 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepacivirus / Neuropatia Óptica Isquêmica / Hepatite C Crônica Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Adult / Female / Humans Idioma: En Ano de publicação: 2008 Tipo de documento: Article