Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors.
Bioorg Med Chem Lett
; 18(7): 2355-61, 2008 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-18342505
ABSTRACT
A series of pyrimidinopyridones has been designed, synthesized and shown to be potent and selective inhibitors of the FMS tyrosine kinase. Introduction of an amide substituent at the 6-position of the pyridone core resulted in a significant potency increase. Compound 24 effectively inhibited in vivo LPS-induced TNF in mice greater than 80%.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridonas
/
Pirimidinas
/
Desenho de Fármacos
/
Receptor 1 de Fatores de Crescimento do Endotélio Vascular
/
Inibidores de Proteínas Quinases
/
Anti-Inflamatórios
/
Antineoplásicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article