Active core structure of terfestatin A, a new specific inhibitor of auxin signaling.
Bioorg Med Chem
; 16(9): 5331-44, 2008 May 01.
Article
em En
| MEDLINE
| ID: mdl-18343120
ABSTRACT
The auxins, plant hormones, regulate many aspects of the growth and development of plants. Terfestatin A (TrfA), a novel auxin signaling inhibitor, was identified in a screen of Streptomyces sp. F40 extracts for inhibition of the expression of an auxin-inducible gene. However, the mode of action of TrfA has not been elucidated. To identify the active core structure, 25 derivatives of TrfA were synthesized and their inhibitory activities against auxin-inducible gene expression were evaluated. The structure-activity relationships revealed the essential active core structure of TrfA, 3-butoxy-4-methylbiphenyl-2,6-diol, which will lead to the design of biotin-tagged active TrfA.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Terfenil
/
Transdução de Sinais
/
Glucosídeos
/
Ácidos Indolacéticos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article