Reaction of rosmarinic acid with nitrite ions in acidic conditions: discovery of nitro- and dinitrorosmarinic acids as new anti-HIV-1 agents.
J Med Chem
; 51(8): 2575-9, 2008 Apr 24.
Article
em En
| MEDLINE
| ID: mdl-18351727
ABSTRACT
Rosmarinic acid was reacted with nitrite ions under acidic conditions to give 6'-nitro- and 6',6''-dinitrorosmarinic acids according to the reaction time. Both compounds were active as HIV-1 integrase inhibitors at the submicromolar level. They also inhibited the viral replication in MT-4 cells with modest and similar selectivity indexes. The nitration of rosmarinic acid strongly improves the anti-integrase inhibition and the antiviral activity without increasing the cellular toxicity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
HIV-1
/
Cinamatos
/
Inibidores de Integrase de HIV
/
Depsídeos
/
Nitritos
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article