Effect of JNK inhibitor during islet isolation and transplantation.
Transplant Proc
; 40(2): 379-81, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-18374074
ABSTRACT
Although islet transplantation has been remarkably improved by the Edmonton protocol, the insulin independence rate after islet transplantation from one donor pancreas has remained low. The c-Jun NH2-terminal kinases (JNKs) are classic stress-activated protein kinases; many cellular stresses have been shown to stimulate JNK activation. JNK in the pancreas is activated during brain death, pancreas procurement, and organ preservation, and its activity is progressively increased during the isolation procedure. Moreover, JNK activity in the transplanted liver after islet transplantation increases markedly within 24 hours. In this study, we show the effect of a JNK inhibitor during islet isolation and transplantation. Use of the JNK inhibitor in pancreas preservation, islet culture, and/or islet transplantation prevents islet cell apoptosis and improves islet graft function. These findings suggest that inhibition of JNK could prevent the impairment of islet cells and improve outcomes after pancreatic islet transplantation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transplante das Ilhotas Pancreáticas
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Ilhotas Pancreáticas
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MAP Quinase Quinase 4
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Inibidores Enzimáticos
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article