Optimization of UDP-N-acetylmuramic acid synthesis.
Pharmazie
; 63(2): 102-6, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-18380394
ABSTRACT
UDP-N-acetylmuramic acid (UDP-MurNAc) is a substrate of MurC, an important enzyme in the intracellular pathway of bacterial peptidoglycan biosynthesis. Various approaches towards preparation of UDP-MurNAc have been published but these synthetic preparations were shown to include many problematic steps. An optimization study with the focus on muramyl phosphate and UMP-morpholidate coupling was performed, resulting in a synthetic procedure enabling robust and easily reproducible production on a multi-gram scale.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Uridina Difosfato Ácido N-Acetilmurâmico
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article