Feasibility of induction heating using a sintered MgFe2O4 needle for minimally invasive breast cancer therapy.
Anticancer Res
; 28(1A): 69-74, 2008.
Article
em En
| MEDLINE
| ID: mdl-18383826
ABSTRACT
BACKGROUND:
This study investigated a novel approach for tumor ablation therapy using an alternating magnetic field combined with a sintered MgFe2O4 needle. This method differs from radiofrequency ablation (RFA) by dielectric heating with regard to the heating mechanism and improves some weak points of these conventional thermotherapies. MATERIALS ANDMETHODS:
Nude mice mimicking human breast cancer BT474 were treated using this method. The extent of tumor death was assessed after ablation.RESULTS:
Staining with hematoxylin and eosin showed gradual expansion of the pyknotic area until 48 h after ablation. Nicotinamide adenine dinucleotide diaphorase staining also showed complete tumor death by 48 h after treatment. The ablation area was well controlled and reablation was not necessary. The tumor could be completely controlled using this method without any risk of skin burn.CONCLUSION:
This novel ablation therapy appeared to be more effective and less invasive for treatment of breast cancer treatment than RFA.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Compostos Férricos
/
Ablação por Cateter
/
Óxido de Magnésio
/
Agulhas
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article