[Suppressive effects of safflower yellow on immune functions].
Zhongguo Yao Li Xue Bao
; 12(6): 537-42, 1991 Nov.
Article
em Zh
| MEDLINE
| ID: mdl-1840455
ABSTRACT
Safflower yellow (SY) extracted from Carthamus tinctorius L contained chalconoid compounds, 75% of which was safflomin A. SY ip 50-450 mg.kg-1.d-1 x 6-8 d in mice decreased serum lysozyme concentration and phagocytosing functions of both peritoneal macrophages and peripheral leukocytes; diminished the production of plaque forming cells, specific rosette forming cells, and antibody; inhibited delayed type hypersensitivity reaction and the activation of T suppressor cells elicited by supraoptimal immunization. Experiments in vitro showed inhibitory effects on [3H]TdR incorporation during human peripheral T- and B-lymphocyte proliferation by SY 0.03-3.0, 0.1-2.0 mg.ml-1 respectively, murine mixed lymphocyte culture response and the production of interleukin-2 by SY 0.1-2.5 mg.ml-1. In conclusion, SY produced declines in both nonspecific and specific immune functions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Chalcona
/
Imunossupressores
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
Zh
Ano de publicação:
1991
Tipo de documento:
Article