Initiation of protein synthesis: a target for antimicrobials.
Expert Opin Ther Targets
; 12(5): 519-34, 2008 May.
Article
em En
| MEDLINE
| ID: mdl-18410237
ABSTRACT
BACKGROUND:
Translation initiation is a basic and universal biological process that employs significantly different components and displays substantially different mechanisms in bacterial, archaeal and eukaryotic cells. A large amount of detailed mechanistic and structural information on the bacterial translation initiation apparatus has been uncovered in recent years.OBJECTIVE:
to understand which translation initiation steps could represent a novel or underexploited target for the discovery of new and specific antibacterial drugs.METHODS:
Brief descriptions of the properties and mechanism of action of the major antibiotics that have a documented direct inhibitory effect on bacterial translation initiation are presented. RESULTS/CONCLUSIONS:
Considerations and predictions concerning a future scenario for research and identification of bacterial translation initiation inhibitors are presented.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Biossíntese de Proteínas
/
Inibidores da Síntese de Proteínas
/
Antibacterianos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article