Internally coated endotracheal tubes with silver sulfadiazine in polyurethane to prevent bacterial colonization: a clinical trial.
Intensive Care Med
; 34(6): 1030-7, 2008 Jun.
Article
em En
| MEDLINE
| ID: mdl-18418571
ABSTRACT
OBJECTIVE:
Coated medical devices have been shown to reduce catheter-related infections. We coated endotracheal tubes (ETT) with silver sulfadiazine (SSD), and tested them in a clinical study to assess the feasibility, safety, and efficacy of preventing bacterial colonization.DESIGN:
A prospective, randomized clinical trial, phase I-II.SETTING:
Academic intensive care unit (ICU).PARTICIPANTS:
Forty-six adult patients expected to need 12-24 h of intubation were randomized into two groups.INTERVENTIONS:
Patients were randomized to be intubated with a standard non-coated ETT (St-ETT, n=23; control group), or with a SSD-coated ETT (SSD-ETT, n=23). MEASUREMENTS ANDRESULTS:
Coating with SSD prevented bacterial colonization of the ETT (frequency of colonization SSD-ETT 0/23, St-ETT 8/23; p<0.01). No organized bacterial biofilm could be identified on the lumen of any ETT; however, SSD was associated with a thinner mucus layer (in the SSD-ETT secretion deposits ranged from 0 to 200 microm; in the St-ETT deposits ranged between 50 and 700 microm). No difference was observed between the two groups in the tracheobronchial brush samples (frequency of colonization SSD-ETT 0/23, St-ETT 2/23; p=0.48). No adverse reactions were observed with the implementation of the novel device.CONCLUSION:
SSD-ETT can be safely used in preventing bacterial colonization and narrowing of the ETT in patients intubated for up to 24 h (mean intubation time 16 h).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfadiazina de Prata
/
Ventiladores Mecânicos
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Contaminação de Equipamentos
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Desinfetantes
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Pneumonia Associada à Ventilação Mecânica
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Intubação Intratraqueal
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article