Cholesterol absorption from the intestine is a major determinant of reverse cholesterol transport from peripheral tissue macrophages.
Arterioscler Thromb Vasc Biol
; 28(7): 1296-7, 2008 Jul.
Article
em En
| MEDLINE
| ID: mdl-18420997
ABSTRACT
OBJECTIVE:
We examined the effect of ezetimibe, a cholesterol absorption (CA) inhibitor, and genetic determinants of CA on reverse cholesterol transport (RCT) from subcutaneously injected macrophages using a new dual isotope label technique. METHODS ANDRESULTS:
Treatment of C57BL/6J mice with ezetimibe decreased dietary CA by 86% and increased RCT from peripheral tissue macrophages (PTM) by 6-fold (P<0.0001). Moreover, congenic 14DKK mice with a modest 41% decrease in dietary CA displayed a 67% increase in RCT from PTM (P<0.007).CONCLUSIONS:
These findings indicate that pharmacological and genetic modifiers of cholesterol absorption are major determinants of reverse cholesterol transport from peripheral tissue macrophages.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Azetidinas
/
Colesterol na Dieta
/
Absorção Intestinal
/
Intestinos
/
Macrófagos
/
Anticolesterolemiantes
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article