Fine-tuned growth phase control of dps, encoding a DNA protection protein, by FIS and H-NS.
Mol Microbiol
; 68(6): 1345-7, 2008 Jun.
Article
em En
| MEDLINE
| ID: mdl-18433444
ABSTRACT
Dps, a ferritin-like DNA-binding protein, protects bacterial DNA against oxidative stress and hyper-compacts the nucleoid into a crystalline-like structure. In Escherichia coli, transcription of dps from a single promoter is directed by sigma S-RNA polymerase in stationary phase and by sigma 70-RNA polymerase in fast-dividing cells exposed to oxidative stress. In this issue of Molecular Microbiology, Grainger and co-workers demonstrate that the nucleoid-associated proteins, FIS and H-NS, control sigma factor selection at the dps promoter by a novel mechanism. The finding suggests a simple mechanism of growth phase control of Dps production and has implications for the response to oxidative stress by pathogenic enterobacteria.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas da Membrana Bacteriana Externa
/
Proteínas de Bactérias
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DNA Bacteriano
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Proteínas de Escherichia coli
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Fator Proteico para Inversão de Estimulação
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Proteínas de Ligação a DNA
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Escherichia coli
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article