The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors.
Bioorg Med Chem Lett
; 18(11): 3386-91, 2008 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-18455394
ABSTRACT
The 'NMDA hypofunction hypothesis of schizophrenia' can be tested in a number of ways. DAO is the enzyme primarily responsible for the metabolism of d-serine, a co-agonist for the NMDA receptor. We identified novel DAO inhibitors, in particular, acid 1, which demonstrated moderate potency for DAO in vitro and ex vivo, and raised plasma d-serine levels after dosing ip to rats. In parallel, analogues were prepared to survey the SARs of 1.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirróis
/
Ácidos Carboxílicos
/
D-Aminoácido Oxidase
/
Inibidores Enzimáticos
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article