MLL insertion with MLL-MLLT3 gene fusion in acute leukemia: case report and review of the literature.
Cancer Genet Cytogenet
; 183(1): 53-9, 2008 May.
Article
em En
| MEDLINE
| ID: mdl-18474298
ABSTRACT
A new chromosomal insertion involving the MLL gene was detected by fluorescence in situ hybridization in a patient with acute myeloblastic leukemia (AML) and a t(9;11)(p21;q13). Genomic polymerase chain reaction confirmed the MLL-MLLT3 gene fusion. A review of the literature on MLL insertions shows that the opposite orientation of the genes involved in the fusion plays a role in the genesis of the rearrangement in most of the cases reported.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Nucleares
/
Leucemia Mieloide Aguda
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Proteínas de Fusão Oncogênica
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Mutagênese Insercional
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Proteína de Leucina Linfoide-Mieloide
Limite:
Adult
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Female
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Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article