Grapefruit juice and its furocoumarins inhibits autoinducer signaling and biofilm formation in bacteria.
Int J Food Microbiol
; 125(2): 204-8, 2008 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-18504060
ABSTRACT
Cell-to-cell communications in bacteria mediated by small diffusible molecules termed as autoinducers (AI) are known to influence gene expression and pathogenicity. Oligopeptides and N-acylhomoserine lactones (AHL) are major AI molecules involved in intra-specific communication in gram-positive and gram-negative bacteria respectively, whereas boronated-diester molecules (AI-2) are involved in inter-specific communication among both gram-positive and gram-negative bacteria. Naturally occurring furocoumarins from grapefruit showed >95% inhibition of AI-1 and AI-2 activities based on the Vibrio harveyi based autoinducer bioassay. Grapefruit juice and furocoumarins also inhibited biofilm formation by Escherichia coli O157H7, Salmonella typhimurium and Pseudomonas aeruginosa. These results suggest that grape fruit juice and furocoumarins could serve as a source to develop bacterial intervention strategies targeting microbial cell signaling processes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Furocumarinas
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Contaminação de Alimentos
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Biofilmes
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Bactérias Gram-Negativas
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Bactérias Gram-Positivas
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article