Library synthesis using 5,6,7,8-tetrahydro-1,6-naphthyridines as scaffolds.
J Comb Chem
; 10(4): 534-40, 2008.
Article
em En
| MEDLINE
| ID: mdl-18517255
ABSTRACT
The chemistry of 5,6,7,8-tetrahydro-1,6-naphthyridine scaffolds, synthesized by intramolecular cobalt-catalyzed [2 + 2 + 2] cyclizations, has been exploited for library synthesis. Urea, amide, and sulfonamide formations were used in the synthesis of a 101-membered library. Screening of the library for antituberculosis activity revealed three lead compounds.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hidrogênio
/
Naftiridinas
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article