Systemic vasoconstriction induced by inhibition of nitric oxide synthesis is attenuated in conscious dogs with heart failure.
Cardiovasc Res
; 25(5): 438-40, 1991 May.
Article
em En
| MEDLINE
| ID: mdl-1855247
ABSTRACT
STUDY OBJECTIVE:
The aim was to test the hypothesis that endothelium dependent vasomotor control is impaired in heart failure. DESIGN ANDSUBJECTS:
The haemodynamic effects of NG-nitro-L-arginine (NNA), an inhibitor of nitric oxide synthesis, were studied in five dogs with and without pacing induced heart failure. MAINRESULTS:
In healthy dogs, NNA increased total peripheral resistance and arterial pressure, decreasing cardiac output and heart rate. These effects were partially reversed by L-arginine. In dogs with heart failure, NNA did not change any haemodynamic variable. However, L-arginine decreased total peripheral resistance.CONCLUSIONS:
These findings support a physiological role for endothelium derived nitric oxide in control of vascular resistance and are in agreement with the hypothesis that endothelium dependent vasomotion may be impaired in heart failure.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vasoconstrição
/
Insuficiência Cardíaca
/
Óxido Nítrico
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article