Censoring of autoreactive B cell development by the pre-B cell receptor.
Science
; 321(5889): 696-9, 2008 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-18566249
ABSTRACT
Antibody diversity occurs randomly as B cells recombine their immunoglobulin (Ig) heavy- and light-chain genes during development. This process inevitably generates reactivity against self structures, and several mechanisms prevent the development of autoreactive B cells. We report here a role for the pre-B cell receptor, composed of Ig heavy and surrogate light chains, in the negative selection of cells expressing Ig heavy chains with the potential to generate autoantibodies. Surrogate light-chain-deficient (SLC-/-) mice harbored elevated levels of antinuclear antibodies (ANAs) in their serum and showed evidence of escape of pre-B cells expressing prototypic autoantibody heavy chains from negative selection, leading to mature autoantibody secreting CD21-CD23- B cells in the periphery. Thus, the pre-B cell receptor appears to censor the development of certain autoantibody-secreting cells and may represent an important factor in multifactorial autoimmune diseases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Linfócitos B
/
Autoimunidade
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Tolerância a Antígenos Próprios
/
Células Precursoras de Linfócitos B
/
Receptores de Células Precursoras de Linfócitos B
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article