Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein.
FEBS Lett
; 582(17): 2479-83, 2008 Jul 23.
Article
em En
| MEDLINE
| ID: mdl-18588880
ABSTRACT
Caloric restriction (CR) is known to promote longevity in various species. Sirtuin-mediated deacetylation has been shown to be related to the promotion of longevity in some species. Here, we show that CR of rats led to an increase in the level of Werner syndrome protein (WRN), a recognized DNA repair protein. In addition, CR simultaneously increased the level of SIRT1, a mammalian sirtuin. In HEK293T cells, sirtuin inhibitors decreased the WRN level, and this effect was suppressed by proteasomal inhibitors. Furthermore, we found a decrease in the WRN level in Sirt1-deficient mice. These results indicate that sirtuin-mediated deacetylation stabilizes WRN. STRUCTURED SUMMARY:
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sirtuínas
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Restrição Calórica
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Exodesoxirribonucleases
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RecQ Helicases
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article