4-Hydroxy-5-pyrrolinone-3-carboxamide HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 18(14): 3865-9, 2008 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-18595690
ABSTRACT
The viral enzyme integrase is essential for the replication of HIV-1 and, after the discovery of Isentress, represents a validated target for anti-retroviral therapy. Incorporation of the dihydroxycarbonyl pharmacophore into a pyrrolinone scaffold led to the discovery of 5-pyrrolinone-3-carboxamides as a structurally diverse class of HIV-1 integrase inhibitors.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirrolidinonas
/
Inibidores de Integrase de HIV
/
Integrase de HIV
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article