Blocking alpha4-integrins - A small molecule approach to treatment of multiple sclerosis.
J Neurol Sci
; 274(1-2): 27-30, 2008 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-18603264
ABSTRACT
Inhibition of leukocyte trafficking using antibody blockade of the alpha4 (alpha4)-integrins has now been validated as a therapeutic approach for the treatment of multiple sclerosis (MS). This positive validation has led to the discovery of small molecule alpha4 antagonists that are progressing through clinical trials. The challenges in development of these antagonists will be discussed along with a clinical update on the most advanced candidates.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Integrina alfa4
/
Anticorpos
/
Esclerose Múltipla
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article