Acute hyperglycaemia induces an inflammatory response in young patients with type 1 diabetes.
Ann Med
; 40(8): 627-33, 2008.
Article
em En
| MEDLINE
| ID: mdl-18608123
ABSTRACT
BACKGROUND:
Patients with type 1 diabetes (T1D) are at a substantially increased risk of cardiovascular disease. Stress-induced hyperglycaemia in turn is shown to worsen the prognosis of patients suffering from an acute myocardial infarction. However, the mechanisms behind these findings are incompletely known.AIM:
To investigate whether markers of chronic inflammation, and oxidative stress respond to acute hyperglycaemia in patients with T1D.METHODS:
The plasma glucose concentration was rapidly raised from 5 to 15 mmol/L in 35 males (22 men with T1D and 13 age-matched non-diabetic volunteers) and maintained for 2 h. All participants were young non-smokers without any signs of diabetic or other complications. Markers of chronic inflammation, and oxidative stress were analysed in serum/plasma samples drawn at base-line and after 120 min of hyperglycaemia.RESULTS:
Compared to normoglycaemia, acute hyperglycaemia increased the interleukin (IL)-6 concentrations by 39% in patients with T1D (P<0.01) and 26% in healthy volunteers (P<0.05). During hyperglycaemia the superoxide dismutase concentration was increased by 17% in the healthy volunteers (P<0.01) and 5% in the patients with type 1 diabetes (P=NS). The increase in tumour necrosis factor (TNF)-alpha was larger in patients with type 1 diabetes than in non-diabetic volunteers (35% versus -10%, P<0.05).CONCLUSIONS:
This study shows that acute hyperglycaemia induces an inflammatory response in patients with type 1 diabetes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Oxidativo
/
Diabetes Mellitus Tipo 1
/
Hiperglicemia
/
Inflamação
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article