Natural killer cells regulate T-cell proliferation during human parainfluenza virus type 3 infection.
J Virol
; 82(18): 9299-302, 2008 Sep.
Article
em En
| MEDLINE
| ID: mdl-18614637
ABSTRACT
Human parainfluenza virus type 3 (HPIV3) is a major respiratory pathogen in humans. Failure to induce immunological memory associated with HPIV3 infection has been attributed to inhibition of lymphocyte proliferation. We demonstrate that the inability of mixed lymphocytes to respond to virally infected antigen-presenting cells is due to an interleukin-2-dependent, nonapoptotic mechanism involving natural killer (NK) cells and their influence is exerted in a contact-dependent manner. These results suggest a novel regulatory mechanism for NK cells during HPIV3 infection, offering an explanation for viral persistence and poor memory responses.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por Respirovirus
/
Células Matadoras Naturais
/
Ativação Linfocitária
/
Linfócitos T
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Vírus da Parainfluenza 3 Humana
/
Células Apresentadoras de Antígenos
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article