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Plasma levels of thromboxane A2 on admission are associated with no-reflow after primary percutaneous coronary intervention.
Niccoli, Giampaolo; Giubilato, Simona; Russo, Eleonora; Spaziani, Cristina; Leo, Andrea; Porto, Italo; Leone, Antonio M; Burzotta, Francesco; Riondino, Silvia; Pulcinelli, Fabio; Biasucci, Luigi M; Crea, Filippo.
Afiliação
  • Niccoli G; Institute of Cardiology, Catholic University of the Sacred Heart, Largo F Vito 1, 00168 Rome, Italy. gniccoli73@hotmail.it
Eur Heart J ; 29(15): 1843-50, 2008 Aug.
Article em En | MEDLINE | ID: mdl-18617477
AIMS: Thromboxane A2 (TXA2) is a key mediator of platelet activation and aggregation, and an important mediator of platelet-induced coronary artery constriction. We sought to investigate whether baseline plasma levels of TXA2 are associated with coronary no-reflow after primary percutaneous coronary intervention (PPCI). METHODS AND RESULTS: A total of 47 consecutive patients (age, 62.5 +/- 12.7; male sex, 76.6%) admitted to our hospital for a first ST-segment elevation myocardial infarction and undergoing PPCI within 12 h of onset of symptoms were enrolled. Admission TXA2 plasma levels were measured by enzyme-linked immunosorbent assay (ELISA). Angiographic no-reflow was defined as a final TIMI flow of
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tromboxano A2 / Angioplastia Coronária com Balão / Fenômeno de não Refluxo / Infarto do Miocárdio Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2008 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tromboxano A2 / Angioplastia Coronária com Balão / Fenômeno de não Refluxo / Infarto do Miocárdio Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2008 Tipo de documento: Article