The effects of Fructus Xanthii extract on cytokine release from human mast cell line (HMC-1) and peripheral blood mononuclear cells.
Immunopharmacol Immunotoxicol
; 30(3): 543-52, 2008.
Article
em En
| MEDLINE
| ID: mdl-18618314
ABSTRACT
In the present study, human mast cell line (HMC-1) and peripheral blood mononuclear cells (PBMNC) were pre-incubated with various concentrations of Fructus xanthii extract solution followed by being stimulated with phorbol myristate acetate and further incubated for 24 hours. The cytokines, in cell culture supernatants, of interleukin (IL)-4, IL-6, IL-8, GM-CSF, and TNF-alpha in the supernatant were measured by enzyme-linked immunosorbent assay. The results demonstrated that Fructus xanthii could modulate the mast cell-mediated and PBMNC-mediated inflammatory and immunological reactions modulated by cytokines. And our study supplied the evidence of the mechanisms of Fructus Xanthii in treating inflammatory and allergic diseases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucócitos Mononucleares
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Citocinas
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Antialérgicos
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Xanthium
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Mastócitos
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Anti-Inflamatórios
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article