[Rho kinase--a new target for pharmacological treatment of an overactive bladder]. / Kinaza Rho--nowy cel dla leczenia farmakologicznego pecherza nadreaktywnego.
Ginekol Pol
; 79(5): 364-9, 2008 May.
Article
em Pl
| MEDLINE
| ID: mdl-18624113
ABSTRACT
Rho kinase plays a key role in the regulation of smooth muscles contraction, including those of the urinary bladder detrusor. Rho kinase pathway modulates the level of phosphorylation of the myosin light chain, mainly through the inhibition of myosin phosphatase. Recent experimental data indicate that its role might be exacerbated in local and systemic pathological conditions which affect the bladder. It seems that Rho kinase inhibitors, such as Y27632, may turn out to be an effective group of drugs in pharmacotheraphy of an overactive bladder (OAB), which will influence the storage phase of the micturition cycle, without interfering with the physiological voiding.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Doenças da Bexiga Urinária
/
Proteínas Serina-Treonina Quinases
/
Inibidores Enzimáticos
/
Amidas
/
Relaxantes Musculares Centrais
Limite:
Animals
/
Humans
Idioma:
Pl
Ano de publicação:
2008
Tipo de documento:
Article