[Experimental treatment using combined Fructus psoraleae and dihydroartemisinin in mouse cryptosporidiosis].
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi
; 26(1): 67-9, 2008 Feb 28.
Article
em Zh
| MEDLINE
| ID: mdl-18637590
ABSTRACT
A combination of Fructus psoraleae (3.4 g/kg) and dihydroartemisinin (60 mg/(kg x d)) was used for 7 d in mice infected with Cryptosporidium parvum infection induced by oral administration of dexamethasone. The results indicated that number of Cryptosporidium parvum oocysts in feces, proportion of CD4+, CD3+ T lymphocytes in blood, serum IFN-gamma, and nitric oxide (NO) content in intestinal tissue were all higher than those of infected control group (P < 0.01). The pathogenic change in intestine of treated mice was lighter than that of infected control. It indicates that the combination of Fructus psoraleae and dihydroartemisinin is effective to mice cryptosporidiosis probably through upregulating serum IFN-gamma, proportion of CD4+ and CD3+ T cells and NO concentration in intestine.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cryptosporidium parvum
/
Criptosporidiose
/
Artemisininas
/
Ficusina
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2008
Tipo de documento:
Article