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Efficient parallel synthesis of macrocyclic peptidomimetics.
Marsault, Eric; Hoveyda, Hamid R; Gagnon, René; Peterson, Mark L; Vézina, Martin; Saint-Louis, Carl; Landry, Annick; Pinault, Jean-François; Ouellet, Luc; Beauchemin, Sophie; Beaubien, Sylvie; Mathieu, Axel; Benakli, Kamel; Wang, Zhigang; Brassard, Martin; Lonergan, David; Bilodeau, François; Ramaseshan, Mahesh; Fortin, Nadia; Lan, Ruoxi; Li, Shigui; Galaud, Fabrice; Plourde, Véronique; Champagne, Manon; Doucet, Annie; Bhérer, Patrick; Gauthier, Maude; Olsen, Gilles; Villeneuve, Gérald; Bhat, Shridhar; Foucher, Laurence; Fortin, Daniel; Peng, Xiaowen; Bernard, Sylvain; Drouin, Alexandre; Déziel, Robert; Berthiaume, Gilles; Dory, Yves L; Fraser, Graeme L; Deslongchamps, Pierre.
Afiliação
  • Marsault E; Tranzyme Pharma Inc. 3001, 12e av. Nord, Sherbrooke, Que., Canada J1H5N4. emarsault@tranzyme.com
Bioorg Med Chem Lett ; 18(16): 4731-5, 2008 Aug 15.
Article em En | MEDLINE | ID: mdl-18640834
A new method for solid phase parallel synthesis of chemically and conformationally diverse macrocyclic peptidomimetics is reported. A key feature of the method is access to broad chemical and conformational diversity. Synthesis and mechanistic studies on the macrocyclization step are reported.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos / Química Farmacêutica Idioma: En Ano de publicação: 2008 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos / Química Farmacêutica Idioma: En Ano de publicação: 2008 Tipo de documento: Article