Anti-HBV agents. Part 1: Synthesis of alisol A derivatives: a new class of hepatitis B virus inhibitors.
Bioorg Med Chem Lett
; 18(16): 4647-50, 2008 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-18644720
ABSTRACT
A series of alisol A derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activities and cytotoxicities in vitro. The preliminary investigation demonstrates that simple modifications of the parent structure of alisol A can produce a number of potentially important derivatives against HBV. The most active anti-HBV compound 6a showed high activities against the secretion of HBV surface antigen (IC(50)=0.024 mM), HBV e antigen (IC(50)=0.028 mM) and remarkable selective indices (SI(HBsAg)>108, SI(HBeAg)>93), which was selected for further evaluation as a novel HBV inhibitor.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Química Farmacêutica
/
Vírus da Hepatite B
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Colestenonas
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Hepatite B
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article