Spiradenoma reminiscent of thymoma: report of a case and review of the literature.
J Cutan Pathol
; 36(2): 246-50, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-18647207
ABSTRACT
BACKGROUND:
Spiradenoma (Sp) is a rare adnexal cutaneous tumor with a prominent vasculature. There are few reports in the literature suggesting that the majority of the cases contain perivascular spaces with numerous lymphocytes, a feature that is characteristic in thymus neoplasms. However, there is little information available about the nature and maturity of the lymphocytes comprising these spaces.METHODS:
We report a case of a Sp that presented as a palpable painless mass in a 45-year-old woman and had histological similarities with thymomas. Furthermore, we compare these two entities in detail, discussing the differences and possible similarities between them.RESULTS:
On histological grounds, the lesion consisted of epithelial lobules with prominent ductal differentiation admixed with conspicuous perivascular spaces containing numerous lymphocytes. Immunohistochemical analysis showed that perivascular spaces contained mostly T lymphocytes (CD3 positive), which in contrast with those seen in most thymomas were mature (CD99, CD1a and Terminal deoxynucleotidyl transferase (Tdt) negative). A detailed comparison between Sps and thymomas shows that there exist several important clinicopathological and cytological differences between these two tumors.CONCLUSIONS:
We suggest that the resemblance between Sps and thymomas is strictly architectural, and we raise some questions regarding the role of these perivascular spaces in tumor development.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias das Glândulas Sudoríparas
/
Timoma
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article