Methods to analyze the palmitoylated CD95 high molecular weight death-inducing signaling complex.
Methods Enzymol
; 442: 83-100, 2008.
Article
em En
| MEDLINE
| ID: mdl-18662565
ABSTRACT
Major work elucidating the structure and function of the CD95 death inducing signaling complex (DISC) was carried in the late 1990s. Since then the DISC has become a paradigm for multiprotein signaling complexes in the apoptosis literature. We analyzed the earliest events of DISC formation with a set of different techniques and found a surprising new characteristic of the CD95 DISC. Data revealed that CD95 is palmitoylated on cysteine 199. This lipid modification enhances receptor aggregation to the high molecular weight DISC.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apoptose
/
Receptor fas
/
Proteínas Adaptadoras de Sinalização de Receptores de Domínio de Morte
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article