Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable.
Bioorg Med Chem Lett
; 18(16): 4723-6, 2008 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-18676144
ABSTRACT
Tie-2 is a receptor tyrosine kinase which is involved in angiogenesis and thereby growth of human tumours. The discovery and SAR of a novel class of imidazole-vinyl-pyrimidine kinase inhibitors, which inhibit Tie-2 in vitro is reported. Their synthesis was carried out by condensation of imidazole aldehydes with methyl pyrimidines. These compounds are lead-like, with low molecular weight, good physical properties and oral bioavailability.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Receptor TIE-2
/
Inibidores de Proteínas Quinases
/
Imidazóis
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article