IGFBP-1 levels in cervicovaginal secretions before and after amniocentesis.
Gynecol Obstet Invest
; 67(1): 9-13, 2009.
Article
em En
| MEDLINE
| ID: mdl-18685257
ABSTRACT
BACKGROUND:
To evaluate the levels of insulin-like growth factor-binding protein-1 (IGFBP-1) in cervicovaginal secretions before and after midtrimester amniocentesis and relate to clinical outcome.METHODS:
100 consecutive amniocentesis procedures were studied. We measured the IGFBP-1 concentration by radioimmunoassay in a cervicovaginal specimen before and after mid-trimester amniocentesis. The post-amniocentesis occurrence of vaginal loss of fluid or blood and abdominal pain was assessed by questionnaire.RESULTS:
In 6 cases there was a 100-fold increase in IGFBP-1 levels after amniocentesis. Loss of fluid per vaginam occurred in 4 (67%) of these pregnancies, compared to 3.2% of pregnancies without significant surge (p < 0.0001). In addition, post-procedural abdominal pain was more common among women with increased IGFBP-1 levels after amniocentesis (50 vs. 14%, p = 0.05). Two (33%) of the 6 patients with increased IGFBP-1 after amniocentesis delivered prior to 37 weeks as a result of spontaneous preterm labor and/or preterm ruptured membranes, compared to 7 (7%) in the group without surge in IGFBP-1 (p = 0.09).CONCLUSION:
Increased post-procedure IGFBP-1 levels are after mid-trimester amniocenteses are related to procedure-related complications like abdominal pain and subsequent amniotic fluid leakage.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ruptura Prematura de Membranas Fetais
/
Colo do Útero
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Proteína 1 de Ligação a Fator de Crescimento Semelhante à Insulina
/
Amniocentese
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
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Pregnancy
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article