Antagonist peptides of the gliadin T-cell stimulatory sequences: a therapeutic strategy for celiac disease.
J Clin Gastroenterol
; 42 Suppl 3 Pt 2: S191-2, 2008 Sep.
Article
em En
| MEDLINE
| ID: mdl-18685513
ABSTRACT
Celiac disease (CD) is a T helper 1-driven autoimmune permanent enteropathy, triggered in susceptible individuals by the ingestion of gluten, the alcohol-soluble protein fraction of some cereals, such as wheat, rye, and barley. The only available treatment for CD is the life-long withdrawal of gluten-containing foods from the diet. Complying with gluten-free diet is difficult and affects the quality of life. Therefore, alternative therapies are being investigated. In this paper, we review a new therapeutic strategy for CD, relying upon peptides that are analogs of gliadin T-cell epitopes that show the ability to down-modulate the immune response pathogenic of CD. These peptides have been obtained artificially by amino acids substitution of gliadin T-cell stimulatory sequences and an immunomodulatory sequence has been identified in the alcohol-soluble protein fraction of cultivars of durum wheat.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Ativação Linfocitária
/
Doença Celíaca
/
Epitopos de Linfócito T
/
Gliadina
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article