Innate immune stimulation of exo-polymers prepared from Cordyceps sinensis by submerged culture.
Appl Microbiol Biotechnol
; 80(6): 1087-93, 2008 Oct.
Article
em En
| MEDLINE
| ID: mdl-18690428
ABSTRACT
After we prepared exo-polymers (EPS) from Cordyceps sinensis by submerged culture, prophylactic intravenous administration (i.v.) of EPS significantly inhibited metastasis in experimental lung metastasis of colon 26-M3.1 carcinoma. Cytotoxicity against Yac-1 tumor cells of natural killer (NK) cell, which was prepared by i.v. of EPS (100 mug/mouse), significantly augmented 2 days after EPS treatment. When NK cells were depleted by rabbit anti-asialo GM1 serum, even the EPS group totally abolished the inhibitory effect on lung metastasis of colon 26-M3.1 cells. EPS can stimulate innate immune system to inhibit tumor metastasis, and its anti-tumor metastasis is associated with macrophage and NK cell activation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
Cordyceps
/
Imunidade Inata
/
Fatores Imunológicos
/
Metástase Neoplásica
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article