The nucleotide sequence and evolution of ovine MHC class II B genes: DQB and DRB.
Immunogenetics
; 34(2): 80-7, 1991.
Article
em En
| MEDLINE
| ID: mdl-1869309
ABSTRACT
The nucleotide sequences of one Ovar-DQB gene, excluding exon 1 and parts of the introns, and one Ovar-DRB pseudogene are presented. The structure of the Ovar-DQB gene is typical of a major histocompatibility complex (MHC) class II B gene and demonstrates considerable sequence similarity with that of humans including such characteristics as the less common polyadenylation signal, ATTAAA. The ovine sequence has a typical 5' acceptor splice signal for exon 5, thus potentially encoding a full length cytoplasmic tail. The Ovar-DRB gene identified in this study was found to be a pseudogene, lacking a defined exon 2 and containing premature termination codons in both exons 3 and 4. The 3' donor splice site of exon 3 is also atypical. A purine-pyrimidine microsatellite repeat, (dC.dA)15, in the 3' region of the pseudogene may be a hotspot for recombination within the ovine DR subregion.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ovinos
/
Antígenos HLA-DQ
/
Antígenos HLA-DR
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article