Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis.
Antimicrob Agents Chemother
; 52(11): 4137-40, 2008 Nov.
Article
em En
| MEDLINE
| ID: mdl-18694944
ABSTRACT
Metronidazole, which is used for the treatment of infections caused by anaerobic organisms, was evaluated in Mycobacterium tuberculosis-infected guinea pigs. M. tuberculosis can adapt to hypoxia, which is present in the primary lesions of infected guinea pigs. Metronidazole treatment (for 6 weeks at 100 mg/kg of body weight) resulted in no reduction in the bacillary burden and significantly worsened lesion inflammation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tuberculose Pulmonar
/
Metronidazol
/
Antituberculosos
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article