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Gamma frailty model for linkage analysis with application to interval-censored migraine data.
Jonker, M A; Bhulai, S; Boomsma, D I; Ligthart, R S L; Posthuma, D; Van der Vaart, A W.
Afiliação
  • Jonker MA; Department of Mathematics, Faculty of Sciences, Vrije Universiteit, De Boelelaan 1081 a, 1081 HV Amsterdam, The Netherlands. majonker@few.vu.nl
Biostatistics ; 10(1): 187-200, 2009 Jan.
Article em En | MEDLINE | ID: mdl-18714083
ABSTRACT
For many diseases, it seems that the age at onset is genetically influenced. Therefore, the age-at-onset data are often collected in order to map the disease gene(s). The ages are often (right) censored or truncated, and therefore, many standard techniques for linkage analysis cannot be used. In this paper, we present a correlated frailty model for censored survival data of siblings. The model is used for testing heritability for the age at onset and linkage between the loci and the gene(s) that influence(s) the survival time. The model is applied to interval-censored migraine twin data. Heritability (obtained from the frailties rather than actual onset times) was estimated as 0.42; this value was highly significant. The highest lod score, a score of 1.9, was found at the end of chromosome 19.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Distribuições Estatísticas / Predisposição Genética para Doença / Ligação Genética / Transtornos de Enxaqueca Tipo de estudo: Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male País/Região como assunto: Europa Idioma: En Ano de publicação: 2009 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Distribuições Estatísticas / Predisposição Genética para Doença / Ligação Genética / Transtornos de Enxaqueca Tipo de estudo: Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male País/Região como assunto: Europa Idioma: En Ano de publicação: 2009 Tipo de documento: Article